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Efficient Synthesis of 3,5,6,7-Tetrahydro-4H-cyclopenta[4,5] thieno[2,3-d]Pyrimidin-4-ones
Authors:LIU Ming-guo  ZHONG Ying  DING Ming-wu
Institution:a Key Laboratory of Pesticide &; Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. China;
b Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang 443002, P. R. China
Abstract:The title compounds 3,5,6,7-tetrahydro-4H-cyclopenta4,5]thieno2,3-d]pyrimidin-4-ones(6) were synthesized by base catalytic reactions of secondary amines with carbodiimides 4,which were obtained from the aza-Wittig reaction of iminophosphoranes(3) with aromatic isoeyanates.
Keywords:Cyclopenta[4  5]thieno[2  3-d]pyrimidin-4-one  Aza-Wittig reaction  Carbodiimide  Isocyanate
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