Features of the reaction of unsymmetrical 2-mercapto-imidazoles with aromatic and aliphatic ketones |
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Authors: | S. G. Dzhavakhishvili A. V. Borisov V. M. Nikitchenko S. N. Kovalenko |
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Affiliation: | (1) State Science Foundation, Science Technology Complex, Institute of Monocrystals, Ukraine National Academy of Sciences, Kharkiv, 61001;(2) National Pharmaceutical University, Kharkiv, 61002, Ukraine;(3) V. N. Karazin National University, Kharkiv, 61077, Ukraine |
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Abstract: | The cyclization of unsymmetrical 2-mercaptoimidazoles with aliphatic and aromatic ketones has been studied. Using 1H NMR and X-ray analysis it has been shown that 4-R1-1H-2-mercaptoimidazoles undergo selective oxidative cyclization to the corresponding 3-R3-2-R2-6-R1-imidazo[2,1-b][1,3]thiazoles while 6-R4-1H-2-mercaptobenzo[d]imidazoles give a mixture of 6-R4-3-R2-2-R3-benzo[4,5]imidazo[2,1-b][1,3]thiazole and 7-R4-3-R2-2-R3-benzo[4,5]imidazo[2,1-b][1,3]thiazole in the ratio 1: 1. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 115–122, January, 2007. |
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Keywords: | 6-R4-3-R2-2-R3-benzo[4,5]imidazo[2,1-b][1,3]thiazole 7-R4-3-R2-2-R3-benzo[4,5]imidazo [2,1-b][1,3]thiazole 3-R3-2-R2-6-R1-imidazo[2,1-b][1,3]thiazoles 6-R1-1H-2-ercaptobenzo[d]imidazoles 4-R1-1H-2-mercaptoimidazole X-ray analysis selectivity |
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