Features of the reaction of unsymmetrical 2-mercapto-imidazoles with aromatic and aliphatic ketones |
| |
| Authors: | S G Dzhavakhishvili A V Borisov V M Nikitchenko S N Kovalenko |
| |
| Institution: | (1) State Science Foundation, Science Technology Complex, Institute of Monocrystals, Ukraine National Academy of Sciences, Kharkiv, 61001;(2) National Pharmaceutical University, Kharkiv, 61002, Ukraine;(3) V. N. Karazin National University, Kharkiv, 61077, Ukraine |
| |
| Abstract: | The cyclization of unsymmetrical 2-mercaptoimidazoles with aliphatic and aromatic ketones has been studied. Using 1H NMR and X-ray analysis it has been shown that 4-R1-1H-2-mercaptoimidazoles undergo selective oxidative cyclization to the corresponding 3-R3-2-R2-6-R1-imidazo2,1-b]1,3]thiazoles while 6-R4-1H-2-mercaptobenzod]imidazoles give a mixture of 6-R4-3-R2-2-R3-benzo4,5]imidazo2,1-b]1,3]thiazole and 7-R4-3-R2-2-R3-benzo4,5]imidazo2,1-b]1,3]thiazole in the ratio 1: 1.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 115–122, January, 2007. |
| |
| Keywords: | 6-R4-3-R2-2-R3-benzo[4 5]imidazo[2 1-b][1 3]thiazole 7-R4-3-R2-2-R3-benzo[4 5]imidazo [2 1-b][1 3]thiazole 3-R3-2-R2-6-R1-imidazo[2 1-b][1 3]thiazoles 6-R1-1H-2-ercaptobenzo[d]imidazoles 4-R1-1H-2-mercaptoimidazole X-ray analysis selectivity |
| 本文献已被 SpringerLink 等数据库收录！ |
|
