The palladium-catalyzed cyanation of indole C-H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source |
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| Authors: | Ren Xinyi Chen Jianbin Chen Fan Cheng Jiang |
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| Institution: | College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325000, People's Republic of China. |
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| Abstract: | A palladium-catalyzed cyanation of the 3-position of indole sp(2) C-H bonds by the combination of NH(4)HCO(3) and DMSO as the "CN" source was achieved to provide aromatic nitriles in moderate to good yields with excellent regioselectivity. It represents a practical and safe cyanation method. |
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