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X‐ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol‐O‐methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity |
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| Authors: | Christian Lerner Armin Ruf Volker Gramlich Birgit Masjost Gerhard Zürcher Roland Jakob‐Roetne Edilio Borroni Franois Diederich |
| Abstract: | |
| Keywords: | Enzyminhibitoren Medizinische Chemie Struktur‐Aktivitä ts‐Beziehungen Transferasen Wirkstoff‐Forschung |