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Novel Thermoreversible Gelation of Biodegradable PLGA‐block‐PEO‐block‐PLGA Triblock Copolymers in Aqueous Solution
Authors:Doo&#x;Sung Lee  Myung&#x;Seob Shim  Sung&#x;Wan Kim  Hyunjung Lee  Insun Park  Taihyun Chang
Abstract:The BAB‐type triblock copolymers composed of a central poly(ethylene oxide) (PEO, M?nPEO = 1 000) block and two poly(D ,L ‐lactic acid)‐co‐(glycolic acid)] end blocks with molecular weights between 900 and 1 600 exhibited an interesting phase transition behavior. The copolymer aqueous solution can form micelles with PLGA loops in the core and a PEO shell and groups of micelles because of bridging between micelles caused by the PLGA blocks with raising temperature. A possible micellar gelation mechanism was suggested.
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