| Abstract: | The common property of organic and inorganic solids of forming pseudopolymorphs are of very high importance in chemical and pharmaceutical industry. Depending on the solvent some compounds form hydrates (with water) or solvates (with other solvents) in different stoichiometric proportions. Pseudopolymorphs exhibit different physical properties like density, habitus, stability, dissolution rate or bioavailability as known for polymorphs. Phase transformations, existing between the different phases, including the anhydrous or nonsolvate form, vary e.g. with temperature, pressure, relative humidity and solvent. If these process parameters are changed, phase transformations cannot be excluded, either prefered or surprising. In a common project industrial relevant properties of pseudopolymorphs are elucidated on a scientific basis. |
