Introduction of fast MR imaging in the assessment of hepatic steatosis |
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| Institution: | 1. Department of Pediatrics, The Ohio State University, Columbus, OH USA;2. Department of Radiology, The Ohio State University, Columbus, OH USA;3. Children''s Hospital, Columbus, OH USA;1. Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China;2. Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China;3. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China;1. Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey;2. Department of Orthopaedics and Traumatology, Medical Faculty, Ordu University, Ordu, Turkey;3. Department of Orthopedic, Medical Faculty, Ataturk University, Erzurum, Turkey;1. Department of Developmental and Regenerative Biology, College of Life Science and Technology, Jinan University, Guangzhou, People''s Republic of China;2. Department of Pathophysiology, Medical College, Jinan University, Guangzhou, People''s Republic of China;3. National Research Institute for Family Planning, Beijing, People''s Republic of China;1. Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig-Holstein, Kiel, Germany;2. Comprehensive Pneumology Center, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany;3. Institute of Human Nutrition and Food Science, Christian-Albrechts-University, Kiel, Germany;4. Institute of Nutritional Physiology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany;1. Department of Cardiovascular Surgery, Japan Organization of Occupational Health and Safety, Osaka Rosai Hospital, Sakai, Osaka, Japan;3. Department of Cardiology, Japan Organization of Occupational Health and Safety, Osaka Rosai Hospital, Sakai, Osaka, Japan;2. Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;4. Department of Biostatistics, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan |
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| Abstract: | We determined the utility of fast gradient echo techniques (modified Dixon method) in the assessment of hepatic fat content. Fast spoiled gradient echo was performed on bovine liver/corn oil homogenates with known fat fractions (FFE) to assess the accuracy of fat quantitation (FFMRI). The pulse sequence was manipulated via alterations in TE (echo time), TR (repetition time), and α (flip angle). In vivo studies were then performed using breath-holding maneuvers on normal adult volunteers and subjects at risk to develop hepatic steatosis, with cystic fibrosis or morbid obesity. At out-of-phase, TE, TR, and α were 2.1 ms, 7.3 ms, and 30–50° and in-phase TE, TR, and α were 4.2 ms, 9.3 ms, and 30–50°; FFMRI correlated well with FFE. An elevated fat fraction was observed in a high percentage of subjects with cystic fibrosis and morbid obesity. Fast gradient echo techniques were used successfully in the assessment of hepatic steatosis. The reduced acquisition times permitted in vivo analysis on adults and children using breath hold maneuvers. |
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