Evidence for left-right asymmetries in the proton MRS of brain in normal volunteers |
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| Affiliation: | 1. School of Electronic and Information Engineering, Beijing Jiaotong University, Shangyuan Village No 3 in Haidian, Beijing, China;2. Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;1. Department of Biomedical Engineering, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea;2. Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea;3. Department of Radiology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea;4. Department of Neurology, Johns Hopkins University, Hopkins Bayview Medical Center, Baltimore, MD, USA;1. Institute of Surgical Pathology, University Hospital Zurich, Switzerland;2. Institute of Physiology, University of Zurich, Switzerland;3. Department of Urology, University Hospital Zurich, Switzerland;4. Department of Oncology, University Hospital Zurich, Switzerland;5. Department of Oncology, University Hospital Vienna, Austria;1. University of Helsinki, Helsinki University Hospital, Department of Obstetrics and Gynaecology, Haartmaninkatu 2, 00290 Helsinki, Finland;2. University of Turku and Turku University Central Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland |
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| Abstract: | Although there is ample evidence in the literature for structural, functional and physiological asymmetries in the two hemispheres of human brain, direct evidence of a similar asymmetry in the in vivo distribution of brain metabolites has been lacking. In this study, the existence of chemical asymmetries in six different regions in normal human brain has been probed with single voxel proton spectroscopy using the STEAM technique in 100 normal right-handed male volunteers. Significant interhemispheric differences in the spectra were observed for all the regions studied in all the volunteers, although statistically significant asymmetries existed only for temporal, occipital and parietal regions. In addition to proven structural and functional asymmetries in the human brain, in vivo evidence of chemical asymmetry has been provided using Magnetic Resonance Spectroscopy (MRS). |
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