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Protein release from poly(ortho ester) extruded rods |
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| Authors: | Alexandra Rothen‐Weinhold John Barr Steven Y. Ng Hui‐Rong Shen Robert Gurny Jorge Heller |
| Abstract: | Poly(ortho ester) rods containing 15 wt% FITC‐BSA were prepared by extruding an intimate mixture of finely powdered polymer and protein at a temperature where protein activity is retained. After an induction period, linear in vitro release kinetics were obtained with concomitant polymer weight loss. |
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