N,N-dimethyl-beta-alanine as an inexpensive and efficient ligand for palladium-catalyzed Heck reaction |
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Authors: | Cui Xin Li Zhe Tao Chuan-Zhou Xu Yu Li Juan Liu Lei Guo Qing-Xiang |
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Affiliation: | Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. |
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Abstract: | N,N-Dimethyl-beta-alanine was found to be a more powerful phosphine-free ligand than the previously reported ligand, N,N-dimethylglycine, in the Pd-catalyzed Heck reaction for a variety of aryl bromides, aryl iodides, and activated aryl chlorides with a practical turnover number of 10(3). Both kinetic and theoretical studies suggested that N,N-dimethyl-beta-alanine led to faster oxidative addition of an aryl halide to Pd than N,N-dimethylglycine. [reaction: see text] |
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