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Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity |
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| Authors: | Andreas?Lüthi Martin?A?Wikstr?m Mary?J?Palmer Paul?Matthews Tim?A?Benke John?TR?Isaac |
| Institution: | (1) MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, UK;(2) Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland;(3) Department of Neuroscience, Karolinska institutet, S-171 77 Stockholm, Sweden;(4) MacKay Institute, School of Life Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK;(5) Pediatrics, Neurology and Pharmacology, UCHSC, 4200E.9th Ave, Box B182, Denver, CO 80262, USA;(6) National Institutes of Health, 37 Convent Drive, Building 35/Room 3C-1002, MSC 3701, Bethesda, Maryland 20892–3701, USA |
| Abstract: | BackgroundKnowledge of how synapses alter their efficiency of communication is central to the understanding of learning and memory. The most extensively studied forms of synaptic plasticity are long-term potentiation (LTP) and its counterpart long-term depression (LTD) of AMPA receptor-mediated synaptic transmission. In the CA1 region of the hippocampus, it has been shown that LTP often involves a rapid increase in the unitary conductance of AMPA receptor channels. However, LTP can also occur in the absence of any alteration in AMPA receptor unitary conductance. In the present study we have used whole-cell dendritic recording, failures analysis and non-stationary fluctuation analysis to investigate the mechanism of depotentiation of LTP. |
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