Formation of budesonide/α-lactose glass solutions by ball-milling |
| |
Authors: | E Dudognon JF Willart F Capet M Descamps |
| |
Institution: | a Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, Université des Sciences et Technologies de Lille, ERT 1018, F-59655 Villeneuve d'Ascq Cedex, France b AstraZeneca, Research and Development, Analytical Development, Lund S-22187, Sweden |
| |
Abstract: | The possibility to obtain amorphous budesonide stabilised by blending with an excipient characterised by a higher glass transition temperature, namely α-lactose, has been studied. We carried out the mixing of the two compounds at room temperature by ball-milling. The four obtained blends (containing, respectively, 10, 30, 50 and 70%w of budesonide) are X-ray amorphous and exhibit a single glass transition located between the ones of pure milled crystalline compounds. This revealed that the two amorphous phases are miscible whatever the composition and sufficiently mixed to relax as a whole. Ball-milling thus appears as a powerful tool to form amorphous molecular alloys with enhanced stability properties. |
| |
Keywords: | 61 43 &minus j 61 43 Fs 65 60 +a 81 20 Wk |
本文献已被 ScienceDirect 等数据库收录! |
|