|
|||||
|
|
F 2-FDG NMR imaging of the brain in rat |
|
| Authors: | Tsutomu Nakada Ingrid L. Kwee Beatrice V. Griffey Richard H. Griffey |
| Affiliation: | a Neurochemistry Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553, USA b Department of Neurology, University of California, Davis, California 95616, USA c NMR Facility, University of California, Davis, California 95616, USA d Center for Non-Invasive Diagnosis, University of New Mexico, Albuquerque, New Mexico 87131, USA |
| Abstract: | Images of the rat head reflecting glucose utilization were obtained using 2-fluoro-2-deoxy-D-glucose (2-FDG) and 19F nuclear magnetic resonance (NMR) imaging. Spatial heterogeneity of glucose utilization in the rat head was clearly demonstrated showing significantly higher glucose utilization in the brain as compared to the surrounding tissues. Although the potential adverse effects of the high doses of 2-FDG (400 mg/kg) needed to perform the study preclude immediate application of this technique to clinical quantitative glucose utilization studies, the present study shows potential for future development of glucose utilization imaging by NMR. |
| Keywords: | Author Keywords: Nuclear magnetic resonance imaging 2-fluoro-2-deoxy-D-glucose Cerebral glucose utilization |
| 本文献已被 ScienceDirect 等数据库收录！ | |