Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder |
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Authors: | Craig F Ferris Mads F Rasmussen Tara Messenger Gary Koppel |
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Affiliation: | (1) Program in Behavioral Neuroscience, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA;(2) Laboratory of Neuropsychiatry, University of Copenhagen, Copenhagen, Denmark;(3) Department of Chemistry, Butler University, Indianapolis, 46208, USA |
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Abstract: | Background Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder. In golden hamsters, arginine vasopressin microinjections into the anterior hypothalamus trigger robust grooming and flank marking, a stereotyped scent marking behaviors. The intensity and repetition of the behaviors induced by arginine vasopressin is somewhat reminiscent of Obsessive Compulsive Disorder in humans. The present experiments were carried out to test whether pharmacological agents used to alleviate obsessive compulsive disorder could inhibit arginine vasopressin-induced flank marking and grooming. |
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