CuCl2 heterogenized on metformine‐modified polystyrene resin as an antibacterial agent and recyclable nanocatalyst for Ullmann‐type C‐N coupling reactions

Merrifield Resin was functionalized with metformine and applied as a solid support to immobilize the CuCl₂. The Ps‐Met/CuCl₂ was characterized by several techniques including Fourier transform infrared (FTIR), field emission scanning electron microscopy (FESEM), energy‐dispersive X‐ray spectroscopy (EDX), wavelength‐dispersive X‐ray spectroscopy (WDX) and inductively coupled plasma (ICP). The Ps‐Met/CuCl₂ was used as an efficient recyclable solid nanocatalyst for N‐arylation of indole and aniline through coupling reactions of Ullmann‐type C‐N. The advantages of this method are easy workup, improved yields, and simple recovery via filtration. Ultimately, the Ps‐Met/CuCl₂ antibacterial property was examined against two bacteria (Staphylococcus aureus (Staph. aureus) and Escherichia coli (E. coli)) and indicated its antibacterial performance against gram negative (E. coli) bacteria and gram positive (Staph. aureus).