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Siderophore Transport in Mycobacteria Analyzed by Mössbauer Spectroscopy: Possible Routes to Novel Antibiotics against These Organisms? |
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| Authors: | B. F. Matzanke U. Möllmann R. Reissbrodt V. Schünemann A. X. Trautwein |
| Affiliation: | 1. Isotopenlabor, Technisch-Naturwissenschaftliche Fakult?t, Medizinische Universit?t, D-23538, Lübeck, Germany 2. Hans-Kn?ll-Institut für Naturstoff-Forschung (HKI), D-07708, Jena, Germany 3. Robert Koch Institut, D-38843, Wernigerode, Germany 4. Institut für Physik, Medizinische Universit?t, D-23538, Lübeck, Germany |
| Abstract: | Iron uptake of the 57Fe-siderophores ferricrocin, rhizoferrin and citrate in M. smegmatis was analyzed by in situ Mössbauer spectroscopy. Siderophore dependent uptake and metabolic utilization patterns of 57Fe were found. Rhizoferrin is accumulated in the organism and, therefore, represents a suitable candidate for the synthesis of novel siderophore-antibiotics conjugates. |
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