| 海藻糖、龙胆二糖、蜜二糖键合硅胶手性固定相的制备和性能 |
| |
| 引用本文： | 宋卿,李芙蓉,字敏,彭雅,袁黎明. 海藻糖、龙胆二糖、蜜二糖键合硅胶手性固定相的制备和性能[J]. 化学研究, 2009, 20(2): 95-97 |
| |
| 作者姓名： | 宋卿 李芙蓉 字敏 彭雅 袁黎明 |
| |
| 作者单位： | 云南师范大学,化学化工学院,云南,昆明,650092;云南省疾病预防控制中心,云南,昆明,650022;云南师范大学,化学化工学院,云南,昆明,650092 |
| |
| 摘 要： | 合成了海藻糖、龙胆二糖、蜜二糖三种二糖类键合硅胶高效液相色谱手性固定相，采用湿法装柱制备了色谱柱．在高效液相色谱正相条件下，该类固定相对醇类、胺类、氨基酸类对映异构体以及一些手性药物表现出了一定的拆分效果．特别是海藻糖固定相在所拆分的9种手性化合物中，有6种手性化合物能得到较好的分离，表现出较好的手性分离性能．并且手性固定相之间具有较好的互补性．
|
| 关 键 词： | 海藻糖 龙胆二糖 蜜二糖 手性固定相 手性拆分 高效液相色谱 |
Preparation and Properties of Trehalose, Gentiobiose and Melibiose Bonded Silica Gel Chiral Stationary Phases |
| |
| SONG Qing,LI Fu-rong,ZI Min,PENG Ya,YUAN Li-ming. Preparation and Properties of Trehalose, Gentiobiose and Melibiose Bonded Silica Gel Chiral Stationary Phases[J]. Chemical Research, 2009, 20(2): 95-97 |
| |
| Authors: | SONG Qing LI Fu-rong ZI Min PENG Ya YUAN Li-ming |
| |
| Affiliation: | SONG Qing, LI Fu-rong, ZI Min, PENG Ya, YUAN Li-ming( 1. School of Chemistry and Chemical Engineering, Yunan Normal University, Kunming 650092, Yunnan, China 2. Ynanan Centre For Disease Control and Prevention, Kunming 650022, Yunnan, China) |
| |
| Abstract: | Trehalose,gentiobiose,melibiose bonded silica gel chiral stationary phases were prepared.In the normal phase condition of high-performance liquid chromatography,some enantiomers including alcohols,amines,amino acids and chiral drugs could be separated by these chiral columns.The results showed that these chiral columns possessed better separation ability to chiral compound,and there was a good complement for enantioselectivity between the chiral stationary phases. |
| |
| Keywords: | trehalose gentiobiose melibiose chiral stationary phase enantioseparation high-performance liquid chromatography |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
