(SR/RS)-cyclohexanyl PNAs: conformationally preorganized PNA analogues with unprecedented preference for duplex formation with RNA |
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| Authors: | Govindaraju T Kumar Vaijayanti A Ganesh Krishna N |
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| Institution: | Organic Chemistry Division (Synthesis), National Chemical Laboratory, Pune 411008, India. |
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| Abstract: | PNA oligomers H-GTAGATCAT-lys-NH2 with cis-(1S,2R/1R,2S)-cyclohexyl-T (III) in the backbone form PNA:RNA duplexes with Tm approximately 30-50 degrees C higher than that of PNA:DNA duplexes. In comparison, cis-(1S,2R/1R,2S)-cyclopentyl PNA-T (IV) form highly stable duplexes with both RNA and DNA without discrimination. |
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