| 氨布洛芬合成工艺的优化 |
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| 引用本文： | 钟光祥,蒋剑松,陈路路. 氨布洛芬合成工艺的优化[J]. 合成化学, 2010, 18(1) |
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| 作者姓名： | 钟光祥 蒋剑松 陈路路 |
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| 作者单位： | 浙江工业大学,药学院,浙江,杭州,310032 |
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| 摘 要： | 对氨布洛芬的合成工艺进行了优化。以甲苯为溶剂,布洛芬经酰氯化制得布洛芬酰氯;K2CO3作缚酸剂,布洛芬酰氯与乙醇胺完成酰胺化反应合成了氨布洛芬,收率94.4%,纯度99.09%。
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| 关 键 词： | 氨布洛芬 布洛芬 工艺优化 药物合成 |
Optimization on Synthetic Technology of Aminoprofen |
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| ZHONG Guang-xiang,JIAN Jia-song,CHEN Lu-lu. Optimization on Synthetic Technology of Aminoprofen[J]. Chinese Journal of Synthetic Chemistry, 2010, 18(1) |
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| Authors: | ZHONG Guang-xiang JIAN Jia-song CHEN Lu-lu |
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| Abstract: | Synthtic technology of Aminoprofen was optimized.Aminoprofen in yield of 94.4% with the purity of 99.09% was synthesized by a two-step reaction of acyl chlorination from Ibuprofen and SOCl_2 in toluene,and amidation from Ibuprofen chloride and ethanolamine using K_2CO_3 as the acid binding agent. |
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| Keywords: | Aminoprofen Ibuprofen technology optimization acyl chlorination amidation drug synthesis |
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