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AIEgen based light-up probes for live cell imaging |
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| Authors: | Jing Liang Guangxue Feng Ryan Tsz Kin Kwok Dan Ding Benzhong Tang Bin Liu |
| Institution: | 1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, singaporecity, 117585, Singapore 2. NUS Environmental Research Institute, National University of Singapore, 5A Engineering Drive 1, singaporecity, 117411, Singapore 3. Department of Chemistry, Division of Biomedical Engineering, the Hong Kong University of Science and Technology, Kowloon, Hong Kong, China 4. SCUT-HKUST Joint Research Laboratory, Guangdong Innovative Research Team, Guangzhou, 510640, China 5. State Key Laboratory of Luminescent Materials and Devices, Guangzhou, 510640, China 6. South China University of Technology, Guangzhou, 510640, China 7. Institute of Materials Research Engineering, Agency for Science, Technology and Research, 3 Research Link, singaporecity, 117602, Singapore |
| Abstract: | Fluorescent light-up probes comprising a tetraphenylethene unit with aggregation-induced emission (AIE) characteristics and a water-soluble peptide have been designed and synthesized which provide cell membrane and nuclear permeability to live cells. This strategy has offered new opportunities for the development of probes with light-up ability and good signal-to-noise ratio. The selectivity or targeting specificity is determined by the peptide sequence, i.e. a nuclear localization signal that leads to nucleus imaging and a cell biomarker targeting peptide that offers specific light-up imaging of HT-29 cells. |
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