Voltammetric quantitation at the mercury electrode of the anticholinergic drug flavoxate hydrochloride in bulk and in a pharmaceutical formulation |
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| Authors: | M.M. Ghoneim M.A. El-Attar S.A. Razeq |
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| Affiliation: | (1) Analytical Chemistry Research Unit, Chemistry Department, Faculty of Science, Tanta University, 31527 Tanta, Egypt;(2) Department of Analytical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, 11754 Nacer City-Cairo, Egypt |
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| Abstract: | Flavoxate hydrochloride, 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4-H-chromene-8-carboxylate, is a smooth muscle antispasmodic. Its electrochemical behavior was studied at the mercury electrode in buffered solutions containing 30% (v/v) methanol using dc-polarography, differential-pulse polarography, cyclic voltammetry, and linear sweep-and square-wave adsorptive stripping voltammetry. Sensitive and precise procedures were developed for determination of bulk flavoxate hydrochloride and in the pharmaceutical formulation Genurin® S.F, without sample pretreatment or extraction. Limits of quantitation (LOQ) of 1 × 10?5, 5 × 10?6, 1 × 10?8 and 1 × 10?9 M flavoxate hydrochloride were achieved by dc-polarography, differential-pulse polarography, linear sweep and square-wave adsorptive stripping voltammetric, respectively.  | |
| Keywords: | Flavoxate hydrochloride Genurin? tablets polarography cyclic voltammetry adsorptive stripping voltammetry quantitation |
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