2-氨基-1,3,4-噻二唑的抗水稻白叶枯病机制的探讨

药师寺国人等于1971年发现2-氨基-1,3,4-噻二唑(ATDA)具有优越的抗水稻白叶枯病菌的性能,并发现这种性能可被烟酰胺抵消.一般认为,ATDA的作用与细菌细胞中烟酰胺的代谢有关.为了探明ATDA的活性与结构的关系,并从中找出有效的同类化合物,进一步了解这个药剂的抗病机制,我们合成了几类新的噻二唑化合物,连同以前报导的

THE MECHANISM OF ANTIBACTERIAL ACTIVITY OF 2-AMINO-1,2,3-THIADIAZOLE IN CONTROLLING LEAF BLIGHT OF RICE

The synthesis of 11 novel compounds of 5-substituted 2-amino-l,3,4-thiadiazole and 2-substituted amino-l,3,4-thiadiazoles are described.The bactericidal activity against Xanthomonas campestris pv oryzae in vivo of about 30 ATDA analogues is observed.2-Amino-5-car-boxyl-l,3,4-thiadiazole exhibites an excellent bactericidal activity.It is postulated that the acive compound which can serve as the competitor of nicotinamide in metabolite.system in bacteria cell seems to be 2-amino-5-carboxyl-l,3,4-thiadiazole rather than ATDA itself.