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Neolamarckines A and B, new indole alkaloids from Neolamarckia cadamba |
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| Authors: | Qureshi Ahmad Kaleem Mukhtar Mat Ropi Hirasawa Yusuke Hosoya Takahiro Nugroho Alfarius Eko Morita Hiroshi Shirota Osamu Mohamad Khalit Hadi A Hamid A Litaudon Marc Awang Khalijah |
| Affiliation: | Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia. |
| Abstract: | Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently. |
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