A new triterpene with antinociceptive activity from Maytenus robusta |
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| Authors: | Niero Rivaldo Mafra Ana P Lenzi Ana C Cechinel-Filho Valdir Tischer Cesar A Malheiros Angela De Souza Marcia M Yunes Rosendo A Delle Monache Franco |
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| Affiliation: | Núcleo de Investiga??es Quimico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), 88.302-202 Itajaí, SC, Brazil. niero@univali.br |
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| Abstract: | A new triterpene 3,15-dioxo-21alpha-hydroxy friedelane has been isolated from methanol extract of Maytenus robusta and its structure elucidated on the basis of spectral analysis. Stigmasterol, friedelin, friedelanol and 3,15-dioxo friedelane were also obtained. 3,15-dioxo-21alpha-hydroxy friedelane was analyzed against the writhing test in mice and exhibited potent dose-dependent effects with an ID50 value of 12.5 +/- 2.1 micromol kg(-1) and a maximal inhibition of 85.90%. It was about 10-fold more active than aspirin and paracetamol, used as reference drugs. |
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