Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer |
| |
Authors: | Cheng Yu C Samia Anna Meyers Joseph D Panagopoulos Irene Fei Baowei Burda Clemens |
| |
Affiliation: | Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA. |
| |
Abstract: | A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|