Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction |
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| Authors: | Kim Joa Kyum Kim Young Ha Nam Ho Tae Kim Bum Tae Heo Jung-Nyoung |
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| Institution: | Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, 100 Jang-dong, Daejeon 305-600, Korea. |
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| Abstract: | A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki-Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formylphenylboronic acid, has been developed. The approach is used to efficiently produce a number of natural aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam. |
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