Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A |
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| Authors: | Giroux Simon Bethke Axel Fielenbach Nicole Antebi Adam Corey E J |
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| Affiliation: | Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. |
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| Abstract: | Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans. |
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