Molecular structure from a single NMR experiment |
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Authors: | Kupce Eriks Freeman Ray |
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Institution: | Varian Limited, 6 Mead Road, Yarnton, Oxford, OX5 1QU, UK. |
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Abstract: | A procedure is described for determining the structure of a small molecule from a single NMR experiment. Several standard NMR sequences are combined so that the essential structural information is obtained in just one pass. Two-dimensional (13)C-(13)C correlations ("INADEQUATE"), single- and multiple-bond (13)C-(1)H correlations, and the conventional (13)C spectrum are recorded in parallel, making use of separate receiver channels for acquisition of (13)C and (1)H signals. The natural-abundance (13)C-(13)C correlation measurements employ a high-sensitivity cryogenically cooled probe, optimized for (13)C detection. An extension of this "all-in-one" sequence with three parallel receivers permits the corresponding natural-abundance (15)N spectra to be included. |
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