羧基导向C―H官能团化/脱羧偶联反应研究进展

以邻或对位取代苯甲酸为原料,通过羧基导向的芳香羧酸邻位碳氢键官能团化继而发生脱羧反应,在原羧基的邻位引入官能团,可以合成传统付-克反应难以合成的间位取代芳香化合物。在此类反应中,羧基充当无痕导向基的功能。本文综述了基于过渡金属催化羧基无痕导向的芳香羧酸脱羧偶联策略,形成新C―C、C―杂键的研究进展。

Carboxyl-Directed C-H Functionalization and Subsequent Decarboxylative Coupling Reactions of Aromatic Acids

Employing ortho or papa-substituted benzoic acids as starting materials, meta-substituted aromatic compounds, which are much more difficult to be prepared by the traditional methods, can be generated via an ortho C―H functionalization directed by carboxyl and subsequent ipso decarboxylation. In these reactions, carboxyl acts as the function of traceless-directing group. This paper reviews the recent progress in the transition-metal-catalyzed decarboxylative coupling reactions of aromatic acids to construct C―C and C―heteroatom bonds with carboxyl as the traceless-directing group.