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Comparison of UPLC and HPLC for Analysis of 12 Phthalates
Authors:Ting Wu  Chao Wang  Xing Wang  Haiqing Xiao  Qiang Ma  Qing Zhang
Institution:1. Institute of Industrial Product Inspection, Chinese Academy of Inspection and Quarantine, 100123, Beijing, China
Abstract:Recent technological advances have resulted in the availability of reversed-phase chromatographic media of particle size 1.7 μm and a liquid-handling system that can be used to operate columns packed with these materials at much higher pressures. This technology, UPLC, has significant theoretical advantages in speed, resolution, and sensitivity of analysis, especially time saving and solvent consumption. The work discussed in this paper with new analytical method used for separation of 12 phthalates and the results were compared with those obtained by use of HPLC. Differences between the techniques, system suitability test data, and advantages and disadvantages of UPLC are discussed.
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