Development of an LC–DAD Method for Analysis of Dexketoprofen, Tramadol, and Haloperidol. Study of the Stability of Mixtures Used for Patient-Controlled Analgesia |
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| Authors: | Antonio Salmerón-García Emilio Lopez-Lopez Eva Román José Cabeza Natalia Navas Luís Fermín Capitán-Vallvey |
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| Institution: | 1. Department of Pharmacognosy, University of Szeged, E?tv?s str. 6., 6720, Szeged, Hungary
2. Department of Pharmacology and Pharmacotherapy, Semmelweis University, Nagyvárad sq. 4., 1089, Budapest, Hungary
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| Abstract: | A novel LC method was applied to enhance the peak resolution of two ecdysteroids: 20-hydroxyecdysone and its 3-epimer. An isocratic solvent system of methanol–water (6:4, v/v) was used on a C18 column, and 100 μL of water was injected during the development in such a manner that the eluted solvent peak appeared exactly between the two overlapping peaks. This resulted in the increased retardation of the later-eluted peak, and in a good separation of the two compounds within 4.5 min. |
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