纳米尺寸多酸脂质体复合物的合成及抗肿瘤活性研究

合成了杂多化合物α-K₈H₆[Si₂W₁₈Ti₆O₇₇](α-Si₂W₁₈Ti₆)的脂质体纳米粒子.通过红外、固体核磁和极谱对其结构进行了表征,使用透射电镜和粒径分析仪研究了纳米粒子的形态和粒径分布.所合成的纳米粒子中多酸化合物仍保持母体的结构,纳米粒子的粒径在60～150nm之间.用MTT法测定了不同粒径纳米粒子的体外抗肿瘤活性.发现多酸化合物形成脂质体纳米粒子后稳定性和活性都有所提高.

Studies on the Synthesis and Antitumor Activity of Polyoxometalate Based Liposome Nanocomplex

Liposome encapsulated polyoxometalate α-K8H6[Si2W18Ti6O77](α-Si2W18Ti6) was synthesized by using liposomal encapsulating method. The structure of nanomaterial were characterized by IR spectra, solid NMR spectra and polarography, and the forms and range in size of the nanomaterial were estimated by using TEM and Zetasizer. The results show that the polyoxometalate in the complex retains its parent structure, and the sizes of the complexes are from 60 to 150 nm. By using MTT method, the antitumoral activities of the complexes were assayed. The results showed that after being encapsulated by the liposome, the stability and antitumoral activity of polyoxometalate were enhanced.