90Y-DOTA-Lanreotide: A potential agent for targeted therapy |
| |
Authors: | U. Pandey S. Banerjee A. Mukherjee H. D. Sarma M. Venkatesh |
| |
Affiliation: | (1) Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, 400 085, India;(2) Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, 400 085, India |
| |
Abstract: | Several human tumors such as neuroendocrine tumors, medullary thyroid carcinoma, etc., express somatostatin receptors which specifically bind somatostatin and its analogues such as lanreotide, octreotide, etc. In order to prepare a therapeutic agent for targeting such tumors, attempts were made to prepare 90Y-DOTA-Lanreotide. Lanreotide could be successfully conjugated with the macrocyclic chelating agent DOTA (1,4,7,10-tetraaza cyclododecane tetracetic acid) which forms stable complexes with 90Y. 90Y-DOTA-Lanreotide could be prepared in >98% radiochemical purity and remained stable for 72 hours at room temperature. The tracer showed specific binding to A431 cells. Biodistribution studies in C57BL6 mice bearing melanoma showed ∼1.3% uptake pergram of tumor at 24-hour p.i. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|