An Adamantane‐Based Building Block for DNA Networks |
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Authors: | Dr. Richa Pathak Prof. Dr. Andreas Marx |
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Affiliation: | Department of Chemistry and Konstanz Research School of Chemical Biology University of Konstanz, Universit?tsstrasse 10, 78457 Konstanz (Germany), Fax: (+49)?7531‐88‐5140 |
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Abstract: | DNA governs the storage and transfer of genetic information through generations in all living systems with the exception of some viruses. Its physicochemical nature and the Watson–Crick base pairing properties allow molecular constructions at nanometer length, thereby enabling the design of desired structural motifs, which can self‐assemble to form large supramolecular arrays and scaffolds. The tailor‐made DNAs have been an interesting material for such designed nanoscale constructions. However, the synthesis of specific structures with a desired molecular function is still in its infancy and therefore has to be further explored. To add a new dimension to this approach, we have synthesized a rigid three‐way branched adamantane motif, which is capable of forming highly stable DNA networks. The moiety generated could serve as a useful building block for DNA‐based nanoconstructions. |
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Keywords: | adamantane branched DNA DNA oligonucleotides self‐assembly |
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