Two‐Photon Fluorescent Probes for Metal Ions |
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| Authors: | Prof. Dr. Hwan Myung Kim Prof. Dr. Bong Rae Cho |
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| Affiliation: | 1. Division of Energy Systems Research, Ajou University, Suwon, 443‐749 (Korea), Fax: (+82)?31‐219‐1615;2. Department of Chemistry, Research Institute for Natural Sciences, Korea University, 1‐Anamdong, Seoul, 136‐701 (Korea), Fax: (+82)?2‐3290‐3544 |
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| Abstract: | Two‐photon microscopy (TPM) has become an indispensible tool in biology and medicine owing to the capability of imaging the intact tissue for a long period of time. To make it a versatile tool in biology, a variety of two‐photon probes for specific applications are needed. In this context, many research groups are developing two‐photon probes for various applications. In this Focus Review, we summarize recent results on model studies and selected examples of two‐photon probes that can detect intracellular free metal ions in live cells and tissues to provide a guideline for the design of useful two‐photon probes for various in vivo imaging applications. |
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| Keywords: | fluorescent probes in vivo imaging metal ions nonlinear spectroscopy two‐photon microscopy |
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