In(OTf)3‐Catalyzed Synthesis of Functionalized 1,5‐Benzodiazepines from o‐Phenylenediamine and Alkyl Propiolates under Solvent‐Free Reaction Conditions |
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| Authors: | Haisheng Wu Jin Yang Lei Wang |
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| Affiliation: | 1. Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China;2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China |
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| Abstract: | A simple, environmental‐friendly, and practical method for the synthesis of benzodiazepine derivatives through a reaction of substituted o‐phenylenediamines with alkyl propiolates has been developed. The reactions generated the 1,5‐benzodiazepines in good to excellent yields in the presence of catalytic amount of In(OTf)3 under solvent‐free reaction conditions. |
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| Keywords: | benzodiazepines o‐phenylenediamines alkyl propiolates In(OTf)3 solvent‐free |
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