Isosteviol‐amino Acid Conjugates as Highly Efficient Organocatalysts for the Asymmetric One‐pot Three‐component Mannich Reactions |
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Authors: | Yajie An Qian Qin Chuanchuan Wang Jingchao Tao |
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Institution: | Department of Chemistry, New Drug Research and Development Center, Zhengzhou University, Zhengzhou, Henan 450052, China |
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Abstract: | Isosteviol‐amino acid conjugates were synthesized and used as chiral catalysts for the asymmetric three‐component Mannich reaction with hydroxyacetone as donor molecule. Good yields (up to 98%) and excellent stereoselectivities (up to 97:3 dr and 99% ee) were achieved in a short reaction time. In addition, syn‐ or anti‐configurations of α‐hydroxy‐β‐amino carbonyl compounds were obtained as main products with different chiral catalysts. |
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Keywords: | isosteviol‐amino acid conjugates asymmetric catalysis mannich reaction hydroxyacetone enantioselectivity |
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