Encapsulation of Pyrene‐Functionalized Poly(benzyl ether) Dendrons into a Water‐Soluble Organometallic Cage |
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Authors: | Anaïs Pitto‐Barry Nicolas P E Barry Dr Olivier Zava Prof Robert Deschenaux Dr Bruno Therrien |
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Institution: | 1. Institut de Chimie, Université de Neuchatel, Ave de Bellevaux 51, CH‐2000, Neuchatel (Switzerland), Fax: (+41)?32‐7182511;2. Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH‐1015 Lausanne (Switzerland) |
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Abstract: | Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P1 and P2) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules encapsulated in the arene–ruthenium metalla‐cage, Ru6(p‐cymene)6(tpt)2(donq)3]6+ ( 1 ]6+) (tpt=2,4,6‐tri(pyridin‐4‐yl)‐1,3,5‐triazine; donq=5,8‐dioxydo‐1,4‐naphthoquinonato). The host–guest properties of P1? 1 ]6+ and P2? 1 ]6+ were studied in solution by NMR and UV/Vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water‐soluble host–guest systems was evaluated on human ovarian cancer cells. |
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Keywords: | anticancer compounds dendrimer drug delivery host– guest chemistry metalla‐cage |
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