Heterodiene syntheses—XII : The conformational analysis of cis and trans 2-alkoxy-4-phenyl-2,3-dihydropyran[2,3-c] pyrazoles: Steric interactions and the anomeric effect |
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Authors: | G Desimoni L Astolfi M Cambieri A Gamba G Tacconi |
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Institution: | Istituto di Chimica Organica dell''Università 27100 Pavia, Italy |
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Abstract: | The conformational equilibria of a homogeneous series of cis and trans 2-alkoxy-4-phenyl-2,3-dihydropyran2,3-c] pyrazoles have been investigated by a graphical method, and the preferences are rationalized in terms of steric interactions between the 4 and 5-substituents and of the anomeric effect.The anomeric interaction depends upon the nature of the alkoxy group and the conformational free-energy differences correlate with the steric parameters Es. |
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