o-Nitrobenzoyl group as a new amino protecting group for peptide synthesis and the synthesis of some anthranilyl peptides |
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Authors: | AK Koul JM Bachhawat B Prashad NS Ramegowda AK Mathur NK Mathur |
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Institution: | Department of Chemistry, University of Jodhpur, Jodhpur, India |
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Abstract: | N (o-nitrobenzoyl)amino acids can be coupled with other amino acids using DCC and the resulting product on hydrogenation gives peptides, containing the anthranilyl group as —NH2 end group. N (anthranilyl)amino acids or peptides can also be obtained by reaction of isatoic anhydride on amino acids or peptides. The anthranilyl end group is easily cleaved by metal (Cu+2) catalysed hydrolysis to give α-amino acid peptides and the insoluble copper(II) anthranilate. |
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