A New Pyridoxal Derivative for Transamination of N‐Terminus of Proteins |
| |
| Authors: | Meijuan Zhang Xuemei Zhang Juan Li Qingxiang Guo Qin Xiao |
| |
| Institution: | 1. Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China;2. Department of Chemistry, Tsinghua University, Beijing 100084, China |
| |
| Abstract: | A new pyridoxal‐5‐phosphate (PLP) derivative FHMDP was developed for the transamination of different peptides with three most hindered amino acid residues (Leu, Ile, Val) as their N‐terminus. Compared to the previously reported reactions of PLP derivatives, the N‐terminus transamination could be accomplished efficiently with the new compound. |
| |
| Keywords: | transamination N‐terminus protein bioconjugation PLP derivative peptides protein modifications |
|
|
