Small Mesoporous Silica Nanoparticles as Carriers for Enhanced Photodynamic Therapy |
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| Authors: | Jie Zhu Huixiang Wang Lei Liao Lingzhi Zhao Liang Zhou Meihua Yu Prof. Yunhua Wang Prof. Baohong Liu Prof. Chengzhong Yu |
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| Affiliation: | 1. Department of Chemistry and Institute of Biomedical Sciences, Fudan University, 220,Handan Road, Shanghai, (200433) (China), Fax: (86)?216‐564‐1740;2. ARC Centre of Excellence for Functional Nanomaterials and Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia) |
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| Abstract: | Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl2 (82.6 % in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl2 being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl2 at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti‐cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs. |
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| Keywords: | mesoporous photodynamic therapy photosensitizers silica nanoparticles |
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