Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract |
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| Authors: | Hong Cai David P‐. Berry Giuseppe Garcea Karen Brown William P. Steward Andreas J. Gescher |
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| Affiliation: | 1. Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UKHong Cai and Sarah C. Thomasset contributed equally to this work.;2. Department of Hepatobiliary and Pancreatic Surgery, Leicester General, University Hospitals of Leicester, Leicester, UK;3. Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK |
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| Abstract: | Anthocyanins possess cancer chemopreventive properties in preclinical models. Their clinical pharmacology is only poorly understood. In this pilot study, anthocyanins and their metabolites were analysed in the urine of two patients with colorectal liver metastases. They received a single dose of 1.88 g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra‐operatively during liver resection. HPLC‐MS/MS and HPLC‐UV analysis showed there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum. This result is consistent with information obtained in rodents which suggests the stomach is the predominant site for anthocyanin absorption. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | anthocyanins adsorption metabolites human urine |
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