Gold Nanoparticles Carrying Diatomic Molecules (O2 and CO) in Aqueous Solution |
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Authors: | Keiichi Karasugi Dr Hiroaki Kitagishi Prof?Dr Koji Kano |
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Institution: | Department of Molecular Chemistry and Biochemistry, Doshisha University, Kyotanabe, Kyoto 610‐0321 (Japan), Fax: (+81)?774‐65‐6845 |
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Abstract: | Gold nanoparticles (AuNPs) prepared by citrate reduction of aurochloric acid (HAuCl4) were functionalized by tris(4‐sulfonatophenyl)porphinatoiron(III) (FeIIIP2) and poly(ethylene glycol) with thiolated arms (PEG‐SH). FeIIIP2 on the AuNP surface existed as its μ‐oxo dimer, which was reduced by Na2S2O4 to yield monomeric FeIIP2. FeIIP2‐bearing AuNPs were further functionalized through inclusion of two sulfonatophenyl groups of FeIIP2 by a per‐O‐methylated β‐cyclodextrin dimer with a pyridine linker (Py3CD) to obtain AuNPs capable of carrying diatomic molecules in the body. The resulting AuNPs (hemoCD‐AuNPs) bound O2 as well as CO in an aqueous solution. Although a noncolloidal 1:1 complex of 5,10,15,20‐tetrakis(4‐sulfonatophenyl)porphinatoiron(II) and Py3CD injected into the femoral vein of a rat was rapidly excreted in the urine, no excretion was observed with ferric hemoCD‐AuNPs, which were gradually accumulated in the spleen and liver of a rat. These results suggest that hemoCD‐AuNPs can be used as a carrier of diatomic molecules such as O2 and CO in vivo. |
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Keywords: | bioinorganic chemistry carbon monoxide cyclodextrins gold nanoparticles |
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