An efficient one‐pot synthesis of 2‐benzylpyrroles and 3‐benzylindoles |
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| Authors: | Ratnesh Sharma Mangilal Chouhan Divya Sood Vipin A. Nair |
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| Affiliation: | Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, Mohali, Punjab 160 062, India |
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| Abstract: | One‐pot regioselective benzylation of pyrroles and indoles using zirconium tetrachloride is discussed. This has been achieved by in‐situ generation of di(1H‐pyrrol‐1‐yl)zirconium(IV) chloride and di(1H‐indol‐1‐yl)zirconium(IV) chloride. It was observed that benzylation reactions of these complexes using n‐BuLi occurred at C‐2 position for pyrrole and C‐3 for indole. Copyright © 2011 John Wiley & Sons, Ltd. |
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| Keywords: | benzylation zirconium(IV) chloride pyrrole indole |
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