Highly Efficient and Directional Homo‐ and Heterodimeric Energy Transfer Materials Based on Fluorescently Derivatized α,γ‐Cyclic Octapeptides |
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| Authors: | Roberto J Brea María Jesús Pérez‐Alvite Michele Panciera Prof Dr Manuel Mosquera Prof Dr Luis Castedo Prof Dr Juan R Granja |
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| Institution: | 1. Departamento de Química Orgánica y Unidad Asociada al C.S.I.C. Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Campus Vida, Universidad de Santiago, 15782 Santiago de Compostela (Spain), Fax: (+34)?981‐595012;2. Departamento de Química Física y Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Campus Vida, Universidad de Santiago, 15782 Santiago de Compostela (Spain) |
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| Abstract: | Cyclic octapeptides composed of α‐amino acids alternated with cis‐3‐aminocycloalkanecarboxylic acids, self‐assemble as drumlike dimers through β‐sheet‐like, backbone‐to‐backbone hydrogen bonding. Heterodimerization appears to be significantly more favored than homodimerization, and this represents a novel approach for the design and fabrication of highly stable heterodimeric assemblies. A multicomponent equilibrium network based on fluorescently derivatized self‐assembling α,γ‐cyclic octapeptides has been successfully used to form light‐harvesting/light‐converting ensembles with a distinctive organization of donor and acceptor units able to act as efficient artificial photosystems. |
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| Keywords: | amino acids cyclic peptides FRET heterodimers self‐assembly |
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