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The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis |
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| Authors: | Ramon O Bernabeu and Frank M Longo |
| Institution: | 1.Department of Neurology,UCSF/VAMC,San Francisco,USA;2.Institute of Cell Biology and Department of Physiology,University of Buenos Aires,Buenos Aires,Argentina;3.Department of Neurology and Neurological Sciences,Stanford University,Palo Alto,USA |
| Abstract: | BackgroundThe ability to regulate neurogenesis in the adult dentate gyrus will require further identification and characterization of the receptors regulating this process. In vitro and in vivo studies have demonstrated that neurotrophins and the p75 neurotrophin receptor (p75NTR) can promote neurogenesis; therefore we tested the hypothesis that p75NTR is expressed by adult dentate gyrus progenitor cells and is required for their proliferation and differentiation. |
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