| 有机阴离子的人工接受体的合成 |
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| 引用本文： | 陆国元,何卫江.有机阴离子的人工接受体的合成[J].高等学校化学学报,1996,17(3):396-400. |
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| 作者姓名： | 陆国元 何卫江 |
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| 作者单位： | 南京大学化学系 |
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| 摘 要： | 报道以Ｄ－天冬酰胺为起始原料经９步反应合成旋光活性的（２Ｒ，８Ｒ）－二羟甲基－１，５，９－三氮双环〔４．４．０〕癸－９－烯盐酸盐，总产率为２５．４％．
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| 关 键 词： | 接受体 合成 有机阴离子 天冬酰胺 双环胍 |
Synthesis of Artificial Receptor of Organic Anion |
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| LU Guo-Yuan, HE Wei-Jiang,HU Hong-Wen.Synthesis of Artificial Receptor of Organic Anion[J].Chemical Research In Chinese Universities,1996,17(3):396-400. |
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| Authors: | LU Guo-Yuan HE Wei-Jiang HU Hong-Wen |
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| Abstract: | The optically active(2R,8R)-bis(hydroxymethyl)-1,5,9-triazabicyclo4.4.0]dec-9-ene has been synthesized from D-asparaginate with a total yield of 25.4%. In the synthesis,the key intermediate is a thiourea derivative from reduction and coupling of the starting materials and the key reaction is it's methylation and double SN reaction to form bicyclic skeleton.Amino and hydroxy are protected by tosyl and silyl groups which can be cleaved under very mild conditions respectively. The target molecule is a useful intermediate in the construction of chiral and selective receptors of organic anions. |
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| Keywords: | Anion Receptor Synthesis |
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