Synthesis of functionalized chromene and spirochromenes using l-proline-melamine as highly efficient and recyclable homogeneous catalyst at room temperature |
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Authors: | Sakkani Nagaraju Banoth Paplal Kota Sathish Santanab Giri Dhurke Kashinath |
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Affiliation: | 1. Department of Chemistry, National Institute of Technology, Warangal 506 004, India;2. Department of Chemistry, National Institute of Technology, Rourkela 769 008, India |
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Abstract: | An efficient and recyclable homogeneous catalyst is developed using commercially cheap l-proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) via multicomponent reactions at room temperature. Systematic studies were conducted in order to achieve desired reactivity and recyclability of the catalyst using various α-amino acids and aromatic amines as donor-acceptor pairs. Among the screened combinations, l-proline and melamine (3:1 ratio; 3 mol% on total weight) was found to be best catalyst to give the desired products with excellent yields (up to 99%) in very short times (1–15 min) at room temperature in DMSO as solvent. The catalyst was recovered by adding EtOAc and reused up to 5 cycles without losing the catalytic activity. |
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Keywords: | Melamine Recyclable catalyst Homogeneous catalysis Spirooxindole 4H-chromene |
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